Our research centres on the chemical synthesis, radiochemistry, preclinical development and clinical translation of metal-based radiopharmaceuticals for diagnostic PET imaging in cancer and other human diseases
synthesis
Radiochemistry
Preclinical
imaging
clinical
translation
News
21st Feb 20
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Jason publishes a collaborative article with the group of Prof. Neil Vasdev (Toronto) in Molecules
'Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease'
10th Feb 20
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Linus and Mirsche join the group as Bachelor's students. Welcome and good luck with your experiments!
3rd Jan 20
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Jason publishes an article in Inorganic Chemistry
'Predicting the thermodynamic stability of zirconium radiotracers'
21st Nov 19
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Simon and Rachael publish an article in the Journal of Nuclear Medicine
'Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor'
7th Oct 19
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Jason, Melanie, Simon, Rachael and Amaury publish a Concept article in Chemistry - A European Journal
'Photochemical reactions in the synthesis of protein-drug conjugates'
28th Aug 19
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Angelo Frei and Eliane publish an article in Dalton Transactions
'Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold'
24th Aug 19
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Melanie publishes an article in Inorganic Chemistry
'Synthesis and photochemical studies on gallium and indium complexes of DTPA-PEG3-ArN3 for radiolabelling antibodies'
19th Aug 19
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Patricia joins the group as a Master's student with expertise in analytical chemistry. Welcome!
16th Aug 19
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Rachael, Jennifer, Faustine and Melanie present posters at ICBIC, Interlaken
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Rachael wins the poster prize for her excellent work on 'Photoradiolabelled 68GaHBED-CC-azepin-MetMAb'. Congratulations!
13th Aug 19
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Jason presents an invited lecture at the 19th International Conference on Biological Inorganic Chemistry (ICBIC), Interlaken.
1st Aug 19
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Jennifer publishes an article in Chemical Science
'Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles'
15th July 19
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Daniel joins the group as a post-doctoral scientist with expertise in sugar synthesis. Welcome!
12th June 19
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Jason publishes perspective in Drug Target Review
'Radiochemistry and drug synthesis 'in a flash'
12th June 19
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Amaury joins the group as a post-doctoral scientist with expertise in synthesis. Welcome!
23rd May 19
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Jason publishes a collaborative study with Prof. Rachel Codd from the University of Sydney in Inorganic Chemistry
'Endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using metal-templated synthesis'
18th May 19
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Rachael and Melanie publish an article in Bioconjugate Chemistry
'Photoradiosynthesis of 68Ga-labelled HBED-CC-azepin-MetMAb for immuno-PET of c-MET receptors'
23rd Apr 19
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Our photoradiochemical technology is featured in a Press Release from the University of Zurich.
17th Apr 19
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Jennifer receives the Alavi-Mandell Award from the Society of Nuclear Medicine and Molecular Imaging (SNMMI) for her paper in the Journal of Nuclear Medicine
'Advanced methods for radiolabeling multimodality nanomedicines for SPECT/MRI and PET/MRI'. Congratulations!
4th Apr 19
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Faustine receives an extension for her Swiss Government Excellence Scholarship. Congratulations and keep up the great work!
22nd Mar 19
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Rachael publishes an article in the Journal of Nuclear Medicine
'The impact of emerging bioconjugation chemistries on radiopharmaceuticals'.
7th Mar 19
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Simon receives the Mathematics and Natural Science Semester Prize (Autumn 2018) for his Bachelor's thesis. Congratulations!
2nd Mar 19
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Malay, Simon and Larissa publish an article in iScience
'Simultaneous photoradiochemical labelling of antibodies for immuno-PET '.
4th Feb 19
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Larissa publishes an article in Chemical Communications
'Photoactive chelates for radiolabelling proteins'. Highlighted as the Cover Article
4th Feb 19
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Rita Sala Faig joins the group as a visiting PhD student from the University of Barcelona. Welcome!
1st Feb 19
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Jennifer, Faustine, Rachael, Florian and Melanie receive travel bursary awards to attend the International Society of Radiopharmaceutical Sciences (ISRS) conference in Beijing (May 2019). Congratulations!
18th Jan 19
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Faustine wins the the award for 'Best Poster' at the Chemical and Molecular Sciences Zurich (CMSZH) retreat. Congratulations!
4th Dec 18
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Malay and Larissa publish an article in Angewandte Chemie Int. Ed.
'Photochemical conjugation and one-pot radiolabelling of antibodies for immuno-PET'.
Highlighted as the Featured Article and Frontispiece
24th Sept 18
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Jason is interviewed for an article feature in Chemistry World - 'The nuclear option' by James Mitchell Crow
Funding
The Holland Lab thanks the following agencies for generous support of our research:
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European Research Council (ERC) - (Jason Holland, Starting Grant ERC-StG-2015, 'NanoSCAN' #676904)
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Swiss National Science Foundation (SNSF) - (Jason Holland, SNSF Professorship PP00P2_163683)
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Swiss Government Excellence Scholarship - (Faustine d'Orchymont, PhD Student Scholarship, 2017)
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Department of Chemistry, University of Zurich
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Chemical and Molecular Life Sciences Graduate School (CMSZH), University of Zurich
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Krebsliga and the Krebsforschung Schweiz - (Jason Holland, Research Grant KFS-4257-08-2017)
