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Scientific Publications
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Journal Articles

* Corresponding author, † Co-first author

93.  Simon Klingler and Jason P. Holland*

Computational studies on the Carboni-Lindsey reaction

submitted, 2020,

92.  Rachael Fay and Jason P. Holland*

Tuning tetrazole photochemistry for protein ligation and molecular imaging

submitted, 2020,

91.  Sebastian Martin, Roswitha Tönnesmann, Ina Hierlmeier, Stephan Maus, Florian Rosar, Juri Ruf, Jason P. Holland, Samer Ezziddin and Mark D. Bartholomä*

Identification, characterization and suppression of side products formed during the synthesis of [177Lu]Lu-PSMA-617

submitted, 2020,

90.  Jennifer Lamb, Joris Šimaitis, Siriney O. Halukeerthi, Christoph G. Salzmann and Jason P. Holland*

Graphene nanoflake antibody conjugates for multi-modal imaging of tumors

submitted, 2020,

89.  Jason P. Holland*, Daniel F. Earley Amaury Guillou, Rachael Fay Simon Klingler

Photochemical conjugation and the influence of polyethylene glycol linkers on the metabolism and pharmacokinetics of 89Zr-radiolabeled antibodies 

submitted, 2020,

88.  Jennifer Lamb, Faustine d’Orchymont, Rachael Fay, Florian Gribi, Jose Esteban Flores, Melanie Gut, Simon Klingler, Patricia Pires, Jan Bühler, Shamisa Behmaneshfar, Amaury Guillou, Daniel F. Earley and Jason P. Holland* 

Expanding the chemistry palette for radiotracer synthesis

Chimia, 2020, in press. Highlighted as the Front Cover.

87.  Sebastian Martin, Stephan Maus, Tobias Stemler, Florian Rosar, Fadi Khreish, Jason P. Holland, Samer Ezziddin and Mark D. Bartholomä*

Proof-of-concept study of the NOTI chelating platform: Preclinical evaluation of 64Cu-labeled mono- and trimeric c(RGDfK) conjugates

Mol. Imaging Biol., 2020, in press

86.  Amaury Guillou, Daniel F. Earley, Malay Patra and Jason P. Holland*

Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabelled monoclonal antibodies

Nature Protocol, 202015, 3579–3594. DOI: 10.1038/s41596-020-0386-5.

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85.  Amaury Guillou, Daniel F. Earley and Jason P. Holland*

Light-activated protein-conjugation and 89Zr-radiolabelling with water-soluble desferrioxamine derivatives

Chem. Eur. J., 2020, 26, 7185-7189. DOI: 10.1002/chem.202001755. Highlighted as the ‘Cover Feature’.​

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84.  Rachael Fay, Anthony Linden and Jason P. Holland*

PhotoTag – photoactivatable fluorophores for protein labelling

Org. Lett., 202022(9), 3499-3503. DOI: 10.1021/acs.orglett.0c00957


83.  Cassis Varlow, Emily Murrell, Jason P. Holland, Alina Kassenbrock, Whitney Shannon, Steven H. Liang, Neil Vasdev* and Nickeisha A. Stephenson*

Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease; 

Molecules, 2020, 25(4), 982. DOI: 10.3390/molecules25040982.

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82.  Jason P. Holland*

Predicting the thermodynamic stability of zirconium radiotracers

Inorg. Chem., 2020, 59(3), 2070-2082. DOI: 10.1021/acs.inorgchem.9b03515.


81.  Simon Klingler, Rachael Fay and Jason P. Holland*

Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor

J. Nucl. Med., 2020, in press. DOI: 10.2967/jnumed.119.237180.

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80.  Jason P. Holland*, Melanie Gut, Simon Klingler, Rachael Fay and Amaury Guillou

Photochemical reactions in the synthesis of protein-drug conjugates

Chem. Eur. J., 2020, 26, 33-48. DOI: 10.1002/chem.201904059

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79.  Angelo Frei,* Eliane Fischer, Bradley Childs, Jason P. Holland and Roger Alberto

Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold

Dalton Trans., 201948, 14600-14605. DOI: 10.1039/C9DT02506E.

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78.  Jason P. Holland*

Radiochemistry and drug synthesis 'in a flash'

Drug Target Review, 20192, 31-34. Link.

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77.  Melanie Gut and Jason P. Holland*

Synthesis and photochemical studies on gallium and indium complexes of DTPA-PEG3-ArN3 for radiolabelling antibodies

Inorg. Chem., 2019, 58(18), 12302-12310. DOI: 10.1021/acs.inorgchem.9b01802.

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76.  Jennifer Lamb, Eliane Fischer, Martin Rosillo-Lopez, Christoph G. Salzmann and Jason P. Holland*

Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles

Chem. Sci. 201910, 8880-8888. DOI: 10.1039/C9SC03736E.

Highlighted in a press release by the SNSF, and as a ‘Science Concentrate’ in Chima 2019.

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75.  Christopher J. M. Brown, Michael P. Gotsbacher, Jason P. Holland and Rachel Codd*

Endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using metal-templated synthesis

Inorg. Chem., 2019, 58(20), 13591-13603. DOI: 10.1021/acs.inorgchem.9b00878


74.  Rachael Fay, Melanie Gut and Jason P. Holland*

Photoradiosynthesis of 68Ga-labelled HBED-CC-azepin-MetMAb for immuno-PET of c-MET receptors

Bioconjugate Chem., 2019, 30, 1814-1820. DOI: 10.1021/acs.bioconjchem.9b00342.

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73.  Rachael Fay and Jason P. Holland*

The impact of emerging bioconjugation chemistries on radiopharmaceuticals

J. Nucl. Med., 201960, 587-591. DOI: 10.2967/jnumed.118.220806.


72.  Malay Patra, Simon Klingler, Larissa S. Eichenberger and Jason P. Holland*

Simultaneous photoradiochemical labelling of antibodies for immuno-PET

iScience, 2019, 13, 416-431. DOI: 10.1016/j.isci.2019.03.004

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71.  Larissa S. Eichenberger, Malay Patra and Jason P. Holland*

Photoactive chelates for radiolabelling proteins

Chem. Commun., 201955, 2257-2260. DOI: 10.1039/C8CC09660K. Highlighted as the Front Cover.

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70.  Malay Patra, Larissa S. Eichenberger, Gregor Fischer and Jason P. Holland*

Photochemical conjugation and one-pot radiolabelling of antibodiesfor immuno-PET

Angew. Chem. Int. Ed., 2019, 58, 1928-1933. DOI: 10.1002/anie.20181328. Frontispiece, DOI: 10.1002/anie.201980761

Angew Chemie (German), 2019, 131, 1946-1951. DOI: 10.1002/ange.201813287.


69.  Christian Weinmann, Jason P. Holland, Tilman Läppchen, Harald Scherer, Stephan Maus, Tobias Stemler, Hendrik Bohnenberger, Samer Ezziddin, Philipp Kurz* and Mark D. Bartholomä*

Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me

Org. Biomol. Chem., 2018, 16, 7503-7512. DOI: 10.1039/c8ob01981a.

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68.  Jason P. Holland*

Antibody-based radiopharmaceuticals for imaging and therapy 

Special Issue Editorial: J. Labelled Compounds Radiopharm., 2018, 61(9), 610. DOI: 10.1002/jlcr.3636.

67.  Jason P. Holland*

Chemical kinetics of radiolabelling reactions 

Chem. Eur. J., 2018, 24, 16472–16483. DOI: 10.1002/chem.201803261. Frontispiece, DOI: 10.1002/chem.201803262.

66.  Tilman Läppchen, Yvonne Kiefer, Jason P. Holland and Mark Bartholomä*

Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me;

Eur. J. Nucl. Med. Mol. Imaging Radiopharm. Chem., 2018, 3(6), 1-11. DOI: 10.1186/s41181-018-0043-2.

65.  Thomas L. Collier,* Kenneth Dahl, Nickeisha A. Stephenson, Jason P. Holland, Adam Riley, Steven H. Liang and Neil Vasdev

Recent applications of a single quadrupole mass spectrometer in PET radiochemistry 

J. Fluorine Chem., 2018, 210, 46-55. DOI: 10.1016/j.jfluchem.2018.02.009.

64.  Tilman Läppchen, Yvonne Kiefer, Jason P. Holland and Mark Bartholomä*

In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate specific membrane antigen targeting vector

Nucl. Med. Biol., 201860, 45-54. DOI: 10.1016/j.nucmedbio.2018.03.002.

63.  Eszter Boros* and Jason P. Holland*

Chemical aspects of metal ion chelation in the synthesis and application antibody‐based radiotracers

J. Labelled Compounds Radiopharm., 2018, 61(9), 652-671. DOI: 10.1002/jlcr.3590.

62.  Jennifer Lamb and Jason P. Holland*

Advanced methods for radiolabeling multi-modality nano medicines for SPECT/MRI and PET/MRI

J. Nucl. Med., 201859, 382-389. DOI:10.2967/jnumed.116.187419.

61.  Alexander Schmidtke, Tilman Läppchen, Christian Weinmann, Lorenz Bier-Schorr, Manfred Keller, Yvonne Kiefer, Jason P. Holland and Mark D. Bartholomä*

Gallium complexation, stability and bioconjugation of TACN derived chelators with azaheterocyclic arms

Inorg. Chem., 2017, 56(15), 9097-9110. DOI: 10.1021/acs.inorgchem.7b01129.

60.  Eleni Gourni, Luigi Del Pozzo, Mark Bartholomä, Yvonne Kiefer, Philipp T. Meyer, Helmut R. Maecke, and Jason P. Holland*

Radiochemistry and PET imaging of 68Ga-desferrioxamine radiotracers targeting prostate-specific membrane

Mol. Imaging, 2017, 16, 1-11. DOI: 10.1177/1536012117737010.

59.  Jason P. Holland*

The role of molecular imaging in personalised healthcare

Chimia, 2016, (9), 787-795. DOI: 10.2533/chimia.2016.787.

58.  Eszter Boros,* Jason P. Holland, Nathaniel Kenton, Nicholas Rotile and Peter Caravan

Macrocycle-based hydroxamate ligands for stable complexation and immunoconjugation of the PET Isotope 89Zr

ChemPlusChem, 2016, 81(3), 274–281. DOI: 10.1002/cplu.201600003.

57.  Svetlana N. Rylova,* Luigi Del Pozzo, Roswitha Tönnesmann, Anna-Lena Illert, Philipp T. Meyer, Helmut R. Maecke and Jason P. Holland

Immuno-PET imaging of CD-30 positive lymphoma using 89Zr-DFO-AC-10

J. Nucl. Med., 201657, 96-102. DOI: 10.2967/jnumed.115.162735.

56.  David E. Hill and Jason P. Holland*

Computational studies on hypervalent iodonium(III) compounds as activated precursors for 18F radiofluorination of electron-rich arenes

Comput. Theor. Chem., 20151066, 34-56. DOI: 10.1016/j.comptc.2015.05.012.

55.  Steven H. Liang,† Jason P. Holland,† Nickeisha A. Stephenson, Alina Kassenbrock, Benjamin H. Rotstein, Cory Daignault, Rebecca Lewis, Thomas Lee Collier, Jacob M. Hooker and Neil Vasdev*

PET neuroimaging studies of [18F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and nonhuman primates

ACS Chem. Neurosci., 20156, 535-541. DOI: 10.1021/acschemneuro.5b00055.

54.  Nickeisha A. Stephenson, Jason P. Holland, Alina Kassenbrock, Daniel L. Yokell, Steven H. Liang and Neil Vasdev*

Iodonium ylide mediated radiofluorination of 18F-FPEB and validation for human use

J. Nucl. Med., 201556, 489-492. DOI: 10.2967/jnumed.114.151332.

53.  David E. Hill, Neil Vasdev and Jason P. Holland*

Evaluating the accuracy of density functional theory for calculating 1H and 13C NMR chemical shifts in drug molecules

Comput. Theor. Chem., 20151051, 161-173. DOI:10.1016/j.comptc.2014.11.007.

52.  Eszter Boros, Alice M. Bowen, Lee Josephson, Neil Vasdev and Jason P. Holland*

Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles

Chem. Sci., 20156(1), 225-236. DOI: 10.1039/C4SC02778G.

51.  Jason P. Holland* and Neil Vasdev

Charting the mechanism and reactivity of zirconium oxalate with hydroxamate ligands using density functional theory: implications in new chelate design

Dalton Trans., 201443, 9872-9884. DOI: 10.1039/C4DT00733F. Highlighted as the “Cover Picture,” July 2014.

50.  Eszter Boros,* Elena Rybak-Akimova, Jason P. Holland, Tyson Rietz, Nicholas Rotile,  Francesco Blasi,  Helen Day, Peter Müller and Peter Caravan*

Pycup – A bifunctional, cage-like ligand for 64Cu radiolabelling

Mol. Pharmaceuticals, 20141(2), 617-629. DOI: 10.1021/mp400686z.

49.  Neeta Pandit-Taskar,† Joseph A. O’Donoghue,† Volkan Beylergil, Serge Lyaschenko, Shutian Ruan, Steven B. Solomon, Jeremy C. Durack, Jorge A. Carrasquillo, Robert A. Lefkowitz, Mithat Gonen, Jason S. Lewis, Jason P. Holland, Sarah M. Cheal, Victor E. Reuter, Joseph R. Osborne, Massimo F. Loda, Peter M. Smith-Jones, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Michael J. Morris* and Steven M Larson* 89Zr J591 immunoPET imaging in patients with castration-resistant prostate cancer

Eur. J. Nucl. Med. Mol. Imaging, 201441, 2093-2105. DOI: 10.1007/s00259-014-2830-7.

48.  Jason P. Holland, Steven H. Liang, Benjamin H. Rotstein, Thomas Lee Collier, Nickeisha A. Stephenson, Ivan Greguric and Neil Vasdev*

Alternative approaches for PET radiotracer development in Alzheimer’s disease: Imaging beyond plaque

J. Labelled Compds Radiopharm., 201457, 323-331. Highlighted as the “Cover Picture”. 2014. DOI: 10.1002/jlcr.3158.

47.  Benjamin H. Rotstein, Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson and Neil Vasdev*

11CO2 Fixation: A renaissance in PET radiochemistry

Chem. Commun., 201349, 5621-5629. DOI: 10.1039/C3CC42236D. Highlighted as the “Cover Picture”. 2013.

46.  Jason P. Holland,* Albert Kang, Susan Cohrs, Svetlana V. Selivanova, Selena Milicevic Sephton, Thomas Betzel, Daniel Frey, Mara Wieser, Rolf Jaussi, Richard A. Kammerer, Roger Schibli and Eliane Fischer*

Synthesis and evaluation of biphenyl derivatives as kinesin spindle protein inhibitors

Chem. Biodiversity, 201310(4), 538-555. DOI: 10.1002/cbdv.201200400.

45.  Yelena Y. Janjigian,†* Nerissa Viola-Villegas,† Jason P. Holland, Vadim Divilov, Greg Carbonetti, Sean Carlin, Erica M. Gomes DaGama, Gabriela Chiosis, Elisa de Stanchina and Jason S. Lewis*

Monitoring afatinib treatment in HER2 positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET

J. Nucl. Med., 201354, 936-943. DOI: 10.2967/jnumed.112.110239. Featured in a “Health Imaging” press release.

44.  Jason P. Holland,* Michael W. Jones, Susan Cohrs, Roger Schibli and Eliane Fischer*

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

Bioorg. Med. Chem., 201321, 496-507. DOI: 10.1016/j.bmc.2012.11.013.

43.  Jason P. Holland, Paul Cumming and Neil Vasdev*

PET imaging of enzymes in the brain

Amer. J. Nucl. Med. Mol. Imaging, 20133(3), 194-216. Link.

42.  Michael J. Evans, Jason P. Holland, Michael G. Doran, Sarah M. Cheal, Carl Campos, Samuel L. Rice, Sean Carlin, Ingo K. Mellinghoff, Charles L. Sawyers and Jason S. Lewis

Imaging tumor burden in the brain with 89Zr-transferrin

J. Nucl. Med., 201354(1), 90-95. DOI: 10.2967/jnumed.112.109777. Highlighted as the “Cover Picture,” January 2013.

41.  Jason P. Holland,† Michael J. Evans,† Samuel L. Rice, John Wongvipat, Charles L. Sawyers* and Jason S. Lewis*

Annotating MYC status with 89Zr-transferrin imaging

Nature Med., 201218, 1586-1591. DOI: 10.1038/nm.2935. Featured in a SciBX press release.

40.  David Ulmert,† Michael J. Evans,† Jason P. Holland, Samuel L. Rice, John Wongvipat, Kim Pettersson, Per-Anders Abrahamsson, Peter T. Scardino, Steven M. Larson, Hans Lilja, Jason S. Lewis* and Charles L. Sawyers*

Imaging androgen receptor signaling with a radiotracer targeting prostate specific antigen

Cancer Discovery, 20122(4), 320-327. DOI: 10.1158/2159-8290.CD-11-0316. Highlighted as the “Cover Picture,” April 2012. Featured in an AACR video press conference and in a “Spotlight” article.

39.  Jason P. Holland,* Paul Cumming and Neil Vasdev

PET of signal transduction pathways in cancer

J. Nucl. Med., 201253(9), 1333-1336. DOI: 10.2967/jnumed.112.105387.

38.  Linjing Mu, Cindy R. Fischer, Jason P. Holland, Jessica Becaud,  P. August Schubiger,  Roger Schibli,  Simon M. Ametamey,*  Keith Graham, Timo Stellfeld,  Ludger M. Dinkelborg and Lutz Lehmann

18F-radiolabeling of aromatic compounds using triarylsulfonium salts

Eur. J. Org. Chem., 20122012(5), 889-892. DOI: 10.1002/ejoc.201101730.

37.  Alessandro Ruggiero,† Jason P. Holland,† Tvrtko Hudolin,† Larissa Shenker, Anna Koulova, Neil H. Bander, Jason S. Lewis and Jan Grimm*

PET imaging of therapy-induced prostate cancer cell death by targeting the internal epitope of prostate specific membrane antigen

J. Nucl. Med., 201152(10), 1608-1615. DOI: 10.2967/jnumed.111.092098.

36.  Jason P. Holland, Guillaume Normand, Alessandro Ruggiero, Jason S. Lewis and Jan Grimm*

Intra-operative imaging of PET radiotracers using Cerenkov luminescence emissions

Mol. Imaging, 201110(3), 177-186. DOI: 10.2310/7290.2010.00047.

35.  Carola Heneweer,† Jason P. Holland,† Vadim Divilov, Sean Carlin and Jason S. Lewis*

Magnitude of enhanced permeability and retention (EPR) effect in tumors with different phenotypes: 89Zr-albumin as a model system

J. Nucl. Med., 201152(4), 625-633. DOI: 10.2967/jnumed.110.083998.

34.  Alessandro Ruggiero,† Carlos H. Villa,† Jason P. Holland, Shanna R. Sprinkle, Chad May, Jason S. Lewis, David A. Scheinberg and Michael R. McDevitt*

Imaging and treating tumor vasculature with radiolabeled carbon nanotubes

Int. J. Nanomedicine, 20105, 783-802. DOI: 10.2147/IJN.S13300.

33.  Inmaculada Matas Ruiz, George R. Whittell, Benjamin M. Partridge, Jason P. Holland, Mairi F. Haddow, Jennifer C. Green* and Ian Manners*

Synthesis, electronic structure, and reactivity of nickel-, palladium-, and platinum-bridged [1]ferrocenophanes

J. Amer. Chem. Soc., 2010132(38), 13279-13289. DOI: 10.1021/ja103367e.

32.  Jason P. Holland and Jason S. Lewis*

Zirconium-89 chemistry in the design of novel radiotracers for immuno-PET

Technetium and Other Radiometals in Chemistry and Medicine, Eds: Ulderico Mazzi, William C. Eckelman, Wynn A. Volkert, Publisher: Servizi Grafici Editoriali snc, Padova, Italy, 2010, 187-192.

31.  Jason P. Holland, Vadim Divilov, Neil H. Bander, Peter M. Smith-Jones, Steven M. Larson and Jason S. Lewis*

89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo

J. Nucl. Med., 201051(8), 1293-1300. DOI: 10.2967/jnumed.110.076174. Selected as the Journal of Nuclear Medicine’s Editor’s Choice Award for the “Best Basic Science Article,” June 2011.

30.  Alessandro Ruggiero,† Jason P. Holland,† Jason S. Lewis and Jan Grimm*

Cerenkov luminescence imaging of medical isotopes

J. Nucl. Med., 201051(7), 1123-1130. DOI: 10.2967/jnumed.110.076521. Highlighted in a press release by the Society of Nuclear Medicine.

29.  Martin Christlieb,* Jason P. Holland and Jonathan R. Dilworth

Investigation of the UV–Vis absorption of bis(N-methylthiosemicarbazonato) zinc Zn[ATSM]

Inorganica Chim. Acta, 2010363(6), 1133-1139. DOI: 10.1016/j.ica.2009.10.006.

28.  Artem Y. Lebedev, Jason P. Holland and Jason S. Lewis*

Clickable bifunctional radiometal chelates for peptide labeling

Chem. Commun., 201046, 1706-1708. DOI: 10.1039/b924784j.

27.  Jason P. Holland,* and Jennifer C. Green

Evaluation of exchange-correlation functionals for time-dependent density functional theory calculations on metal complexes

J. Comput. Chem., 201031(5), 1008-1014. DOI: 10.1002/jcc.21385.

26.  John G. Woollard-Shore, Jason P. Holland, Michael W. Jones* and Jonathan R. Dilworth*

Nitrite reduction by copper complexes

Dalton Trans., 201039(6), 1576-1585. DOI: 10.1039/b913463h.

25.  Jason P. Holland, Eloisi Caldas-Lopes, Vadim Divilov, Valerie M. Longo, Tony Taldone, Danuta Zatorska, Gabriela Chiosis and Jason S. Lewis*

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using 89Zr-DFO-trastuzumab

PLoS ONE, 20105(1), e8859. DOI: 10.1371/journal.pone.0008859.

24.  Jason P. Holland,* Victoria Fisher, Jennie A. Hickin and Josephine M. Peach*

Pyrene-functionalised copper complexes as potential dual-modality imaging agents

Eur. J. Inorg. Chem., 2010, 1, 48-58. DOI: 10.1002/ejic.200900823. Highlighted as the “Cover Picture,” January 2010.

23.  Jason P. Holland, Matthew J. Williamson and Jason S. Lewis*

Unconventional nuclides for radiopharmaceuticals

Mol. Imaging, 20109(1), 1-20. DOI: 10.2310/7290.2010.00008.

22.  Jason P. Holland,* Michael W. Jones, Paul D. Bonnitcha, Jason S. Lewis and Jonathan R. Dilworth

Functionalised copper-64 bis(thiosemicarbazonato) complexes as precursors of potential PET imaging agents for neurodegenerative disorders

New J. Chem., 200933, 1845-1852. DOI: 10.1039/b902895a. Top 10 New J. Chem. downloaded articles, September 2009.

21.  Jason P. Holland, Yiauchung Sheh and Jason S. Lewis*

Standardized methods for the production of high specific-activity zirconium-89

Nucl. Med. Biol., 200936, 729-739. DOI: 10.1016/j.nucmedbio.2009.05.007. #1 Highest cited article in NMB since 2009.

20.  Peter J. Barnard,* Jason P. Holland, Simon R. Bayly, Thaddeus J. Wadas, Carolyn J. Anderson and Jonathan R. Dilworth*

Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agents

Inorg. Chem., 200948(15), 7117-7126.DOI: 10.1021/ic900307f.

19.  Georgeta Masson, David E. Herbert, George R. Whittell, Jason P. Holland, Alan J. Lough, Jennifer C. Green* and Ian Manners*

Synthesis and reactivity of a silicon-bridged [1]ferroceniumphane

Angew. Chem. Int. Ed., 200948, 4961-4964. DOI: 10.1002/anie.200901213.

18.  Franziska Bell, Jason Holland, Jennifer C. Green* and Michel R. Gagné

Computational studies on the Pt(II)-catalyzed cycloisomerization of 1,6-dienes into bicyclopropanes: A mechanistic quandary evaluated by DFT

Organometallics, 200928, 2038-2045. DOI: 10.1021/om800770x.

17.  Jason P. Holland,* Jeffrey H. Giansiracusa, Stephen G. Bell, Luet-Lok Wong and Jonathan R. Dilworth

In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals

Phys. Med. Biol., 200954, 2103-2119. DOI: 10.1088/0031-9155/54/7/017.

16.  Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth and Jennifer C. Green

Electronic absorption spectroscopy and time-dependent density functional theory calculations on the nickel(II) complex of 1,4-bis(pyrrol-2-ylmethyleneamino)butane

Inorganica Chim. Acta, 2009362(2), 402-406. DOI: 10.1016/j.ica.2008.04.031.

15.  Jason P. Holland, Riccardo Ferdani, Carolyn J. Anderson and Jason S. Lewis*

Copper-64-radiopharmaceuticals for oncologic imaging

PET Clinics, 20094(1), 49-67. DOI: 10.1016/j.cpet.2009.04.013.

14.  Jason P. Holland, Jason S. Lewis and Farrokh Dehdashti*

Assessing tumor hypoxia by positron emission tomography with Cu-ATSM

Q. J. Nucl. Med. Mol. Imaging, 200953, 193-200. Link.

13.  Jason P. Holland,* Jennie A. Hickin, Emma Grenville-Mathers, ThaoNguyen Nguyen, and Josephine M. Peach*

Rapid decomplexation of bis(thiosemicarbazonato)zinc(II) complexes using citric acid

J. Chem. Res., 200812, 702-703. DOI: 10.3184/030823408X380731.

12.  Simon R. Bayly, Robert C. King, Davina J. Honess, Peter J. Barnard, Helen M. Betts, Jason P. Holland, Rebekka Hueting, Paul D. Bonnitcha, Jonathan R. Dilworth, Franklin I. Aigbirhio, and Martin Christlieb*

In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)–glucose conjugate for hypoxia imaging

J. Nucl. Med., 200849, 1862-1868. DOI: 10.2967/jnumed.108.054015.

11.  Helen M. Betts, Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth,* Antony D. Gee and Jason P. Holland

Controlled axial ligation: solid-phase synthesis and purification of metallo-radiopharmaceuticals

Angew. Chem. Int. Ed., 200847(44), 8416-8419. DOI: 10.1002/anie.200801936.

10.  Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* Julia M. Heslop, Eric J. L. McInnes, Christoph G. Salzmann and Amber L. Thompson

Synthesis, X-ray crystallography, spectroelectrochemistry and computational studies on potential copper-based radiopharmaceuticals

Eur. J. Inorg. Chem., 2008, 3549-3560. Highlighted as a “EurBest” article, 20th August 2008. DOI: 10.1002/ejic.200800413.

9.   Jason P. Holland, Peter J. Barnard, Jonathan R. Dilworth,* and David J. Watkin


Acta Crystallogr. E, 2008E64, m773. DOI: 10.1107/S1600536808010684.

8.   Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* and Eric J. L. McInnes

Spectroelectrochemical and computational studies on the mechanism of hypoxia-selectivity of copper radiopharmaceuticals

Chem. Eur. J., 200814, 5890-5907. DOI: 10.1002/chem.200800539.

7.   Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Helen M. Betts, Grant C. Churchill, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green* and Rebekka Hueting

Synthesis, radiolabelling and confocal fluorescence microscopy of styrene derivatised zinc and copper bis(thiosemicarbazonato) complexes

Eur. J. Inorg. Chem., 2008, 1985-1993. DOI: 10.1002/ejic.200701351.

6.   Peter J. Barnard, Simon R. Bayly, Jason P. Holland, Jonathan R. Dilworth* and Philip A. Waghorn

In vitro assays for assessing the stability of new potential copper-based radiopharmaceuticals

Q. J. Nucl. Med. Mol. Imaging, 200852(3), 235-244. Link.

5.   Peter Barnard, Simon Bayly, Helen Betts, Paul Bonnitcha, Martin Christlieb, Jon Dilworth,* Jason Holland and Sofia Pascu

Towards new copper based radiopharmaceuticals

Q. J. Nucl. Med. Mol. Imaging, 200852(2), 174-184. Link.

4.   Andrey Y. Khalimon, Jason P. Holland, Radoslaw M. Kowalczyk, Eric J. L. McInnes, Jennifer C. Green, Philip Mountford* and Georgii Nikonov

Synthesis and molecular and electronic structure of an unusual paramagnetic borohydride complex Mo(NAr)2(PMe3)2(h2-BH4)

Inorg. Chem., 200747, 999-1006. DOI: 10.1021/ic701826v.

3.   Jason P. Holland, Franklin I. Aigbirhio, Helen M. Betts, Paul D. Bonnitcha, Paul Burke, Martin Christlieb, Grant C. Churchill, Andrew R. Cowley, Jonathan R. Dilworth,* Paul S. Donnelly, Jennifer C. Green, Josephine M. Peach, Sridhar R. Vasudevan and John E. Warren

Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: Synthetic platforms towards site-specific radiopharmaceuticals

Inorg. Chem., 200746, 465-485. DOI: 10.1021/ic0615628.

2.   Jason P. Holland, Jennifer C. Green* and Jonathan R. Dilworth*

Probing the mechanism of hypoxia-selectivity of copper bis(thiosemicarbazonato) complexes: DFT calculation of redox potentials and absolute acidities in solution

Dalton Trans., 20066, 783-794. DOI: 10.1039/b512656h. Highlighted as a “Hot Article” and reviewed in Chemistry World, January 2006.

1.   Andrei S. Batsanov, Jonathan C. Collings, Ian J. S. Fairlamb,* Jason P. Holland, Judith A. K. Howard, Zhenyang Lin, Todd B. Marder,* Alex C. Parsons, Richard M. Ward, and Jun Zhu

Requirement for an oxidant in Pd/Cu co-catalyzed terminal alkyne homocoupling to give symmetrical 1,4-disubstituted 1,3-diynes

J. Org. Chem., 200570, 703-706. DOI: 10.1021/jo048428u.

Books and Chapters

Jason Holland

Hypoxia-Selective Copper Radiopharmaceuticals: Rational Design of Novel Imaging Agents

VDM-Verlag, Germany, 15th May 2009. ISBN-13: 978-3-639-15244-9. ISBN-10: 3639152441. (Thesis book)

Brian M. Zeglis, Jason P. Holland, Artem Y. Lebedev, Melchor V. Cantorias and Jason S. Lewis

Radiopharmaceuticals for imaging in oncology with special emphasis on positron-emitting agents

Chapter 3 in Nuclear Oncology – Pathophysiology and Clinical Applications, Eds. H. William Strauss, Giuliano Mariani, Duccio Volterrani, Steven M. Larson. Springer. 2012. ISBN-13: 978-0387488936. ISBN-10: 0387488936. (Book chapter)

Jason P. Holland*

The radiochemistry of seldom-used radionuclides in Nuclear Medicine

Chapter 24 in Radiopharmaceutical Chemistry. Eds: Jason S. Lewis, Albert Windhorst, Brian M. Zeglis. Springer, 2018, in press

Jason P. Holland*

The radiochemistry of zirconium

Chapter XX in The Handbook OF Radiopharmaceuticals.  Eds: Peter Scott and Michael Kilbourn, 2019, in press


Heat-induced radiochemical labeling of an iron-oxide nanoparticle – PCT/US2014/059891 (WO2015054487)

Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction. 

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