Holland Lab

Bioinorganic chemistry (CHE 324)

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•   Metals in Medicine

Radiochemistry & Imaging science (CHE 438)

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•   Advanced Radiochemical Synthesis

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•   Molecular Imaging

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•   Radiochemistry and PET Imaging Practicals

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Bioconjugation chemistry (MDS 101)

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•   Introduction to bioconjugate techniques

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•   Bioconjugation reactions - focus on antibodies

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•   Advanced bioconjugate synthesis - bioorthogonal reactions and enzyme-mediated chemistry

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Medicinal chemistry (CHE 435)

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•   Introduction to radiopharmaceutical science

Photochemistry in synthesis (CHE 746)

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•   Applications of photochemically induced reactions an processes in the design and synthesis of complex molecules 

Old News

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2nd October 20

• Linus completes his Bachelor's thesis. Congratulations and good luck with the remainder of your degree program.

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25nd Sept 20

• Jennifer successfully defends her PhD and becomes the first doctoral student to graduate from the group. Amzing work and well done on passing your degree Dr Lamb! Good luck in your new job at Roche Diagnostics!

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22nd Sept 20

• Patricia passes her Master's degree! Many congratulations and great job.

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22nd July 20

• Amaury, Daniel, Malay and Jason have an article accepted in Nature Protocols

     'Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabelled                       monoclonal antibodies'

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8th June 20

• Jan joins the group as a scientific co-worker. Welcome and good luck!

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13th May 20

• Faustine receives the Chemistry Travel Award 2020 from the Swiss Academy of Sciences (SCNAT) and the Swiss Chemical Society (SCS). Congratulations!

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11th May 20

• Faustine receives the Chemistry and Molecular Sciences Zurich (CMSZH) Travel Award 2020. Congratulations!

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21st Nov 19

• Amaury and Daniel publish an article in Chemistry - A European Journal

       'Light-activated protein-conjugation and 89Zr-radiolabelling with water-soluble desferrioxamine derivatives' 

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21st Nov 19

• Rachael publishes an article in Organic Letters

       'PhotoTag: Photoactivatable fluorophores for protein labeling'      

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26th Feb 20

• Shamisa joins the group as a Master's student. Welcome and good luck!

 

21st Feb 20

• Jason publishes a collaborative article with the group of Prof. Neil Vasdev (Toronto) in Molecules

       'Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease'

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10th Feb 20

• Linus and Mirsche join the group as Bachelor's students. Welcome and good luck with your experiments!

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3rd Jan 20

• Jason publishes an article in Inorganic Chemistry

       'Predicting the thermodynamic stability of zirconium radiotracers'

 

21st Nov 19

• Simon and Rachael publish an article in the Journal of Nuclear Medicine

       'Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor'      

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7th Oct 19

• Jason, Melanie, Simon, Rachael and Amaury publish a Concept article in Chemistry - A European Journal

       'Photochemical reactions in the synthesis of protein-drug conjugates'      

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28th Aug 19

• Angelo Frei and Eliane publish an article in Dalton Transactions

       'Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold'        

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24th Aug 19

• Melanie publishes an article in Inorganic Chemistry

       'Synthesis and photochemical studies on gallium and indium complexes of DTPA-PEG3-ArN3 for radiolabelling                     antibodies'​

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19th Aug 19

• Patricia joins the group as a Master's student with expertise in analytical chemistry. Welcome!

 

16th Aug 19

• Rachael, Jennifer, Faustine and Melanie present posters at ICBIC, Interlaken

• Rachael wins the poster prize for her excellent work on 'Photoradiolabelled 68GaHBED-CC-azepin-MetMAb'. Congratulations!

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13th Aug 19

• Jason presents an invited lecture at the 19th International Conference on Biological Inorganic Chemistry (ICBIC), Interlaken.

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1st Aug 19

• Jennifer publishes an article in Chemical Science

       'Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles'

 

15th July 19

• Daniel joins the group as a post-doctoral scientist with expertise in sugar synthesis. Welcome!

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12th June 19

• Jason publishes perspective in Drug Target Review

       'Radiochemistry and drug synthesis 'in a flash'

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12th June 19

• Amaury joins the group as a post-doctoral scientist with expertise in synthesis. Welcome!

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23rd May 19

• Jason publishes a collaborative study with Prof. Rachel Codd from the University of Sydney in Inorganic Chemistry 

       'Endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using             metal-templated synthesis'

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18th May 19

• Rachael and Melanie publish an article in Bioconjugate Chemistry 

       'Photoradiosynthesis of 68Ga-labelled HBED-CC-azepin-MetMAb for immuno-PET of c-MET receptors'

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23rd Apr 19

• Our photoradiochemical technology is featured in a Press Release from the University of Zurich.

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17th Apr 19

• Jennifer receives the Alavi-Mandell Award from the Society of Nuclear Medicine and Molecular Imaging (SNMMI) for her paper in the Journal of Nuclear Medicine

       'Advanced methods for radiolabeling multimodality nanomedicines for SPECT/MRI and PET/MRI'. Congratulations!

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4th Apr 19

• Faustine receives an extension for her Swiss Government Excellence Scholarship. Congratulations and keep up the great work!

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22nd Mar 19

• Rachael publishes an article in the Journal of Nuclear Medicine 

       'The impact of emerging bioconjugation chemistries on radiopharmaceuticals'.

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7th Mar 19

• Simon receives the Mathematics and Natural Science Semester Prize (Autumn 2018) for his Bachelor's thesis. Congratulations!

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2nd Mar 19

• Malay, Simon and Larissa publish an article in iScience

       'Simultaneous photoradiochemical labelling of antibodies for immuno-PET '.

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4th Feb 19

• Larissa publishes an article in Chemical Communications 

       'Photoactive chelates for radiolabelling proteins'. Highlighted as the Cover Article

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4th Feb 19

• Rita Sala Faig joins the group as a visiting PhD student from the University of Barcelona. Welcome!

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1st Feb 19

• Jennifer, Faustine, Rachael, Florian and Melanie receive travel bursary awards to attend the International Society of Radiopharmaceutical Sciences (ISRS) conference in Beijing (May 2019). Congratulations!

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18th Jan 19

• Faustine wins the the award for 'Best Poster' at the Chemical and Molecular Sciences Zurich (CMSZH) retreat. Congratulations!

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4th Dec 18

• Malay and Larissa publish an article in Angewandte Chemie Int. Ed.

       'Photochemical conjugation and one-pot radiolabelling of antibodies for immuno-PET'.

       Highlighted as the Featured Article and Frontispiece

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24th Sept 18

• Jason is interviewed for an article feature in Chemistry World - 'The nuclear option' by James Mitchell Crow 

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24th Sept 18

• Jason and Mark Bartholomä publish an article in Organic and Biomolecular Chemistry - 'Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me'

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30th Aug 18

• Malay completes his postdoc and leaves the group for an Assistant Professorship position at the Tata Institute of Fundamental Research, Mumbai, India. Very best wishes for your new start.  

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2nd Aug 18

• Larissa completes her Master's thesis. Congratulations on an excellent job and a superb thesis!

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1st Aug 18

• Melanie joins the group as a PhD student. Welcome and good luck.

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9th Jul 18

• Simon Klingler joins the group to work on his Bachelor's thesis

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30th Jun 18

• Jason publishes a 'Concept Article' in Chemistry - A European Journal - ​'Chemical kinetics of radiolabelling reactions' Highlighted as the Frontispiece

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1st Jun 18

• Nofre completes his ERASMUS exchange and returns to the University of Barcelona - Congratulations and good luck!

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17th May 18

• Jason edits a Special Issue of the Journal of Labelled Compounds and Radiopharmaceuticals - 'Antibody-based radiopharmaceuticals for imaging and therapy'​

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2nd May 18

• Jason and Mark Bartholomä publish in the EJNMMI Radiopharmaceutical Chemistry - 'Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me​'